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Master Syllabus

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Administrative Unit: Physical and Biological Sciences Department
Course Prefix and Number: CHEM 422
Course Title: *Biochemistry II
Number of:
Credit Hours 3
Lecture Hours 3
Lab Hours 0
Catalog Description:

The second of a two semester course that outlines the structure, function, and chemical properties of biological molecules. Topics include the catabolism of fatty acid and amino acids, the urea cycle, oxidative phosphorylation of the mitonchondria and chloroplast, the anabolic reactions of lipids, amino acids, nucleotides, and other nitrogen containing compounds, hormonal regulation and integration in mammalian metabolism and extensions of this concept into the function and regulation of genes and chromosomes, and the biological synthesis of DNA, RNA, and protein. Student majoring in Biology of Chemistry must earn a grade of C or higher. Cross-listed as BIOL 422. Prerequisite: BIOL/CHEM 420.

Prerequisite(s) / Corequisite(s):


Course Rotation for Day Program:

Offered  Spring.

Text(s): Most current editions of the following:

Lehninger Principles of Biochemistry
By David Nelson & Michael Cox (Freeman)
Fundamentals of Biochemistry: Life at the Molecular Level
By Donald Voet, Judith Voet & Charlotte Pratt (Wiley)
By Jeremy Berg, John Tymoczko & Lubert Stryer (Freeman)
Course Learning Outcomes
  1. Understand the enzymes and functions of the catabolism of fatty acids and amino acids.
  2. Understand chemiosmotic theory and how it drives oxidative phosphorylation and photophosphorylation.
  3. Investigate the enzymatic biosynthesis of carbohydrates, lipids, and nitrogen containing biomolecules.
  4.  Examine how mammalian metabolism is regulated and integrated by hormones.
  5. Examine the structure and metabolism of DNA and RNA.
  6. Examine protein post-translational modification and metabolism.
Major Topics/Skills to be Covered:
  • Catabolism of fatty acids, amino acids, and the urea cycle

  • Oxidative phosphorylation in the mitochondria and photophosphorylation in the chloroplast

  • Carbohydrate and lipid biosynthesis

  • Biosynthesis of nitrogen containing compounds: amino acids, nucleotides, and hemes

  • Hormonal regulation and integration of mammalian metabolism

  • Structural features of the DNA helix that allow for the packaging of genes into chromosomes

  • The metabolism of DNA, RNA, and proteins

  • The mechanisms of regulating gene expression in prokaryotic and eukaryotic systems


Recommended maximum class size for this course: 25

Library Resources:

Online databases are available at You may access them using your CougarTrack login and password when prompted.

Prepared by: Kent Strodtman Date: August 17, 2016
NOTE: The intention of this master course syllabus is to provide an outline of the contents of this course, as specified by the faculty of Columbia College, regardless of who teaches the course, when it is taught, or where it is taught. Faculty members teaching this course for Columbia College are expected to facilitate learning pursuant to the course learning outcomes and cover the subjects listed in the Major Topics/Skills to be Covered section. However, instructors are also encouraged to cover additional topics of interest so long as those topics are relevant to the course's subject. The master syllabus is, therefore, prescriptive in nature but also allows for a diversity of individual approaches to course material.

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