Methodology and applications in molecular biology, with special emphasis on biotechnology. Prerequisite: BIOL 342 with a grade of C or higher. Concurrent enrollment in BIOL 410L is strongly recommended.
Prerequisite(s) / Corequisite(s):
BIOL 342 with a grade of C or higher. Concurrent enrollment in BIOL 410L is strongly recommended.
Course Rotation for Day Program:
Most current editions of the following:
Molecular biotechnology books designed to introduce a wide range of applications; text should be supplemented with current peer-reviewed journal articles.
An Introduction to Genetic Engineering
By D.S.T. Nicholl (Cambridge University Press) Recommended
By J.E. Smith (Cambridge University Press) Recommended
From Genes to Genomes: Concepts and Applications of DNA Technology
By J.W. Dale & M. vonSchantz (Wiley & Sons) Recommended
An Introduction to Biotechnology
By W.J. Thieman & M.A. Palladino (Pearson Education) Recommended
To examine basic techniques used in molecular biotechnology.
To apply molecular and biotechnology techniques to experimental situations.
To assess the benefits and hazards of molecular biotechnology.
Describe the different techniques used in recombinant DNA technology.
Determine which technique(s) is appropriate in solving a specific experimental problem.
Delineate the steps used in gene manipulation, gene expression techniques, and recombinant protein development, and relate these processes to current commercial and research applications.
Describe the applications of molecular biology in areas such as transgenic plants and animals, vaccines and therapeutic agents.
Assess the realized and/or potential benefits and risks associated with molecular biotechnology.
Explain the processes used to sequence entire genomes, and give examples of the uses and implications of the Human Genome Project.
History of molecular biotechnology
Recombinant DNA technology
Manipulation of gene expression in prokaryotes
Recombinant protein production in eukaryotic cells
Production of therapeutic agents, vaccines, commercial products by recombinant microorganisms
Methodology and applications of genetic engineering of plants
Human molecular genetics, gene therapy
Legal and patent issues in biotechnology
Recommended maximum class size for this course: 20
NOTE: The intention of this master course syllabus is to provide an outline of the contents of this course, as specified by
the faculty of Columbia College, regardless of who teaches the course, when it is taught, or where it is taught. Faculty members teaching this
course for Columbia College are expected to facilitate learning pursuant to the course objectives and cover the subjects listed in the topical
outline. However, instructors are also encouraged to cover additional topics of interest so long as those topics are relevant to the course's
subject. The master syllabus is, therefore, prescriptive in nature but also allows for a diversity of individual approaches to course material.