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Columbia College-San Luis Obispo is located on Highway 1 on the Central California Coast. It is seven miles northwest of San Luis Obispo and seven miles east of Morro Bay. Highway 1 can be reached from both north and south exits of U.S. 101, which runs through the city of San Luis Obispo.

The address is Columbia College-San Luis Obispo Office 3141 at Cuesta College San Luis Obispo, CA 93403.

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